Job Shop Scheduling with Set-up Times, Deadlines and Precedence Constraints* Alkis Vazacopoulos Dash Optimization, Englewood Cliffs, NJ Abstract In the last 15 years several procedures have been developed that can find solutions of acceptable quality in reasonable computing time to Job Shop Scheduling problems in environments that do not involve sequence dependent setup times of machines. The presence of the latter, however, changes the picture dramatically. In this paper we adapt one of the best known heuristics, the Shifting Bottleneck Procedure, to the case when sequence dependent setup times play an important role. This is done by treating the single machine scheduling problems that arise in the process as traveling salesman problems with time windows, and solving the latter by an efficient dynamic programming algorithm. The model treated here also incorporates precedence constraints, release times and deadlines. Computational experience on a vast array of instances, mainly from the semiconductor industry, shows our procedure to substantially advance the state of the art. *joint work with Egon Balas, Carnegie Mellon University Neil Simonetti, Bryn Athyn College of the New Church, Bryn Athyn PA Short Bio Dr. Alkis Vazacopoulos is the President at Dash Optimization, Inc. where works closely with OEMs/ISVs in developing optimization solutions. He also does consulting work with Fortune 500 companies in the areas of finance, marketing optimization, data mining, supply chain, procurement and decision analytics. Dr. Vazacopoulos attended Florida International University and received an MS in Management Information Systems. He then attended the Graduate School of Industrial Administration at Carnegie Mellon University. In 1994 he completed his PhD in Industrial Administration. He has a Bachelors degree from University of Piraeus (Graduate School of Industrial Studies, 1986). Dr. Vazacopoulos worked as an Associate Professor at Fairleigh Dickinson University from 1994 to 2001 and now has Adjunct Professor status. To keep in touch with academia, Dr. Vazacopoulos gives seminars at different universities including: University of Florida, Gainesville, Purdue University, University of Texas-Austin, University of Paris, Imperial College. Dr. Vazacopoulos is Associated Faculty at University of Florida (Department of Industrial Engineering). He is a regular Panelist at National Science Foundation.